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            <h2>
                <span style="color: #222222"><span style="font-family: Helvetica"><span><strong>When energy fails:
                                Edema, heart failure, hypertension, sarcopenia, etc.&nbsp;</strong></span></span></span>
            </h2>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>More than 100 years ago the idea of
                        a morphogenetic field was proposed by A.G. Gurwitsch, as a way to explain the orderly movements
                        of cells in embryos and growing tissues, and to understand the principles that cause cells to
                        change appropriately when their location in the organism changes. For 30 years, the concept
                        guided research in embryology, but also led to important discoveries in the biology of cancer,
                        aging, wound repair, and other important areas. But by the late 1940s, a more abstract approach
                        to biology, based on the gene doctrine of Mendel and Weismann, took charge of academic and
                        governmental biological research. This ideology at first said that organisms are determined by
                        unchanging units of inheritance, "genes," and later when genes were found to be susceptible to
                        mutation, the changes were said to be always random. The Central Dogma of the ideology was that
                        any meaningful, adaptive changes that occur in an organism can't influence the genes. For many
                        years, adaptive changes were said to be nothing but changes in the size or function of existing
                        cells, because the cells of the major organs of the body were supposed to be created before
                        birth, or in infancy.&nbsp;</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Besides the purely ideological
                        commitment to the theory of genes, there were other influences that contributed to the culture
                        of Molecular Biology. People learned histology from slides or pictures made by killing,
                        hardening, dehydrating, and slicing parts of organisms. Biochemists studied the chemistry of
                        life mainly by grinding cells or tissues, and extracting water soluble materials to study the
                        actions of enzymes on various materials. These unrealistic artifacts filled the textbooks and
                        the minds of generations of biologists and physicians. The culture of molecular biology used
                        these artifacts to create theories of embryology and physiology, and holistic ideas such as the
                        developmental field were disregarded.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The mental image of a living
                        organism that has been created by that culture is simply wrong. The concept of a developmental
                        field is essential for understanding embryology, because things that exist on a scale bigger
                        than molecules and cells govern the functions of the molecules and cells, and the principles of
                        embryology don't arbitrarily stop operating at birth, but can be seen to continue operating
                        during maturity and aging. The interactions of cells with their environment are different at
                        different stages of life, but there are commonalities that are extremely important.</span></span
                ></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The processes that govern the
                        pregnant woman's blood circulation, in sustaining the development of a fetus, are very similar
                        to the processes that govern anyone's blood circulation, providing for the maintenance and
                        renewal of all the body's organs. The common problems of pregnancy involving the circulatory
                        system can provide insights into the problems of the various organs that have been the focus of
                        the medical specialties, and to some basic medical issues, including aging, obesity, and
                        inflammation.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The development of a fertilized egg
                        into an embryo consumes energy at a very high rate, and the way the embryo develops depends on a
                        continuously adequate supply of oxygen and sugar, and other nutrients. The intense flow of
                        energy through each stage of a developing structure shapes the following stage. The necessary
                        energy and materials are provided abundantly by the mother's blood. When the development has
                        advanced far enough to make life possible outside the uterus, energy will be used more slowly,
                        for growth, maintenance, and renewal of tissues.&nbsp;</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Failure to renew cells and tissues
                        leads to the loss of function and substance. Bones and muscles get weaker and smaller with
                        aging. Diminished bone substance, osteopenia, is paralleled, at roughly the same rate, by the
                        progressive loss of muscle mass, sarcopenia (or myopenia). The structure of aging tissue
                        changes, with collagen tending to fill the spaces left by the disappearing cells. It's also
                        common for fat cells to increase, as muscle cells disappear.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>When conditions are ideal, as during
                        healthy development in the uterus, tissue damage is corrected by the multiplication of cells to
                        replace any that were lost. But when conditions are less perfect, injuries are imperfectly
                        repaired, usually with highly collagenous scar tissue bridging the area that was destroyed.
                        During this imperfect repair, there is inflammation, which apparently exists to the extent that
                        the substances needed for regeneration are lacking. For example, when oxygen is lacking, lactic
                        acid is likely to be produced, along with increases of pro-inflammatory regulators such as
                        histamine and serotonin, leading to the loss of many important proteins and functions, and the
                        over-production of collagen instead.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Since cellular renewal of tissues,
                        in a healthy individual, is a constant process, we can think of the metabolic rate of a healthy
                        adult as just what is needed to sustain this constant, limited sort of regeneration, but not
                        quite intense enough to produce scarless healing of a wound (without special
                        intervention).</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>If something reduces the systemic
                        ability to produce energy, there will be a gap between the available energy and the energy
                        needed for the constant turnover of cells in each tissue and organ, and a generalized
                        inflammation will develop. The replacement of cells will be slowed, and the organism will
                        mobilize the processes used for producing scar tissue, producing an excess of collagen, filling
                        the spaces left by the lost cells.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>We are susceptible to many things
                        that interfere with energy production---the substitution of iron for copper in the respiratory
                        enzyme, the absorption of endotoxin, the accumulation of PUFA, a deficiency of thyroid hormone,
                        the formation of increased amounts of nitric oxide, serotonin, and histamine, etc. Different
                        environments will condition the way the defensive mechanisms of inflammation are
                        produced.&nbsp;</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Toxemia of pregnancy, or
                        preeclampsia, is a state of generalized inflammation, and some of the causes and remedies are
                        known. Despite the predominance of crazy genetic theories of preeclampsia in 20th century
                        medical literature, there was clear evidence (reviewed by Tom Brewer, Douglas Shanklin, and Jay
                        Hodin) that it was caused by malnutrition, and that it could be cured by adequate protein, salt,
                        and calcium.&nbsp;&nbsp;&nbsp;</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The old medical practice of
                        restricting salt intake during pregnancy was an important factor in causing it, so it's
                        interesting to look at the effects of salt restriction as a treatment for hypertension.</span
                    ></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The pregnant woman's blood volume
                        expands, to permit the supply of energy to match the needs of the embryo. If the blood volume
                        doesn't increase, or if it decreases, as in pregnancy toxemia, her blood pressure will increase.
                        Typically, the decrease of blood volume is accompanied by an increase in the extracellular
                        fluid, edema, resulting from leakage of fluid through the walls of the capillaries, and albumin
                        appears in the urine as it leaks through the capillaries in the kidneys. The amount of blood
                        pumped by the heart, however, is increased in toxemia (Hamilton, 1952), showing that the
                        increased blood pressure is at least partially compensating for the smaller volume of
                        blood.&nbsp;</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>A similar situation,&nbsp;<strong
                        >reduced blood volume and edema, can be seen (Tarazi, 1976) in "essential hypertension," the
                            "unexplained" hi</strong>gh blood pressure that occurs more often with increasing age and
                        obesity. At the beginning of "essential hypertension," the amount of blood pumped is usually
                        greater than normal.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>In both situations, preeclampsia and
                        essential hypertension, there is an increased amount of aldosterone, an adrenal steroid which
                        allows the kidneys to retain sodium, and to lose potassium and ammonium instead. A restriction
                        of salt in the diet causes more aldosterone to be produced, and increased salt in the diet
                        causes aldosterone to decrease. One effect of aldosterone is to increase the production of a
                        substance called vascular endothelial growth factor, VEGF, or vascular permeability factor,
                        which causes capillaries to become leaky, and causes new blood vessels to grow.</span></span
                ></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>While&nbsp;<strong>increased salt in
                            the diet tends to lower both aldosterone and VEGF, reducing the leakiness of blood
                            vessels,&nbsp;</strong>sodium also has a direct effect that tends to prevent the leakage of
                        water and albumin out of the blood vessels, helping to maintain the blood volume which is needed
                        to perfuse the kidneys, preventing them from producing signals to increase blood pressure and
                        aldosterone. There is a large amount of albumin in the blood serum, and sodium ions associate
                        with the negative electrical charges on the albumin molecule. This association causes the
                        complex of albumin and sodium to attract a large amount of water, that is to exert osmotic or
                        oncotic pressure. This oncotic pressure causes any excess extracellular water to be attracted
                        into the blood vessels, preventing edema while maintaining the blood volume. When there is too
                        little sodium, the albumin molecule itself easily leaves the blood stream along with the
                        water.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Instead of considering the
                        significance of sodium's effects on albumin, aldosterone, and VEGF, textbooks have often talked
                        about the factors that "pump" sodium, and factors that specifically regulate the movement of
                        water. Experiments in which an excess of aldosterone is combined with a high salt intake produce
                        increased blood pressure, and--by invoking various genes--salt is said to cause hypertension in
                        certain people. This reasoning is hardly different from the reasoning of the drug companies in
                        the 1950s who said that since women with toxemia have hypertension and edema, they should be
                        treated with a diuretic and a low salt diet, to eliminate water and to reduce blood
                        pressure.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The physiological loss of sodium
                        occurs when energy metabolism fails, as in<strong>diabetes, hypothyroidism, hyperestrogenism,
                            and starvation.&nbsp;</strong>What these conditions have in common is an increased level of
                        free fatty acids in the blood. Increased free fatty acids impair the use of glucose. The
                        consumption of carbohydrate, like an increase of thyroid hormone, insulin, or progesterone,
                        increases the retention of sodium; fructose is the most effective carbohydrate (Rebello, et al.,
                        1983).&nbsp;</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The loss of sodium is often
                        accompanied by the retention of water, reducing the osmotic pressure of the body fluids. The
                        leakiness of blood vessels allows the extracellular fluid volume to increase, as understood in
                        the standard definition of edema. However, when this fluid is hypo-osmotic, it will enter cells,
                        causing them to swell. Cell swelling excites cells (Ayus, et al., 2008; Baxter, et al., 1991),
                        and can kill them if they are unable to produce enough energy to restore their original volume,
                        by measures including the excretion of amino acids and potassium.&nbsp; Both low sodium
                        (hyponatremia) and low osmotic pressure stimulate the adrenergic nervous system.</span></span
                ></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The increase of adrenalin,f caused
                        by a deficiency of sodium, is one of the factors that can increase blood pressure; if the
                        tissues's glycogen stores are depleted, the adrenalin will mobilize free fatty acids from the
                        tissues, which tends to inhibit energy production from glucose, and to increase leakiness. After
                        I had read Tom Brewer's work on preventing or curing preeclampsia with added salt, I realized
                        that the premenstrual syndrome involved some of the features of preeclampsia (edema, insomnia,
                        cramps, hypertension, salt craving), so I suggested to a friend that she might try salting her
                        food to taste, instead of trying to restrict salt to "prevent edema." She immediately noticed
                        that it prevented her monthly edema problem. For several years, all the women who tried it had
                        similarly good results, and often mentioned that their sleep improved. I mentioned this to
                        several people with sleep problems, and regardless of age, their sleep improved when they ate as
                        much salt as they wanted. Around that time, several studies had shown that salt restriction
                        increases adrenalin, and one study showed that most old people on a low sodium diet suffered
                        from insomnia, and had unusually high adrenalin. When they ate a normal amount of salt, their
                        adrenalin was normalized, and they slept better.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>It's very common for physicians who
                        are aware of progesterone's "anti-aldosterone" activity to think that both estrogen and
                        progesterone are responsible for the increased risk of sodium loss in women, especially during
                        pregnancy, but Hans Selye demonstrated that progesterone will normalize sodium retention even
                        when there is no aldosterone at all, following removal of the adrenal glands. It is estrogen
                        which is responsible for the dangerous loss of sodium.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span
                    ></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The ratio of estrogen to
                        progesterone--regardless of age or gender--is an important factor in regulating minerals and
                        water, cell energy metabolism, and blood pressure. The ratios of many other regulatory
                        substances (including serotonin/dopamine, glucagon/insulin, and
                        aldosterone/cortisol+progesterone) vary according to the quality of the individual's level of
                        adaptation to the environment. Improving the environment can shift the ratio in the direction of
                        restoration, rather than mere survival.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Gershom Zajicek and his colleagues
                        have demonstrated an organized renewal of tissues, in which new cells are born with the division
                        of stem cells, and "stream" away from their origin as they mature, and finally are shed or
                        dissolved. A few studies have demonstrated a similar kind of migration of new cells in the brain
                        (Eriksson, et al., 1998; Gould, et al., 1999), a process which differs by the absence of
                        systematic dissolution of mature brain cells. While Zajicek has demonstrated the conversion of
                        one kind of cell, such as a pancreatic ductal epithelial or acinar cell into insulin-secreting
                        beta cells, other researchers have shown that after injury to the pancreas beta cells can be
                        formed from glucagon-secreting alpha cells, as well as from other beta cells.&nbsp;</span></span
                ></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Stress, increasing the need for
                        energy, increases the formation of cortisol and free fatty acids when glucose isn't available,
                        and those--while they provide alternative sources of energy--interfere with the ability to
                        produce energy from glucose. Free fatty acids and cortisol can cause the insulin-secreting beta
                        cells to die. Glucose, and insulin which allows glucose to be used for energy production, while
                        it lowers the formation of free fatty acids, promotes the regeneration of the beta-cells.
                        Although several research groups have demonstrated the important role of glucose in regeneration
                        of the pancreas, and many other groups have demonstrated the destructive effect of free fatty
                        acids on the beta cells, the mainstream medical culture still claims that "sugar causes
                        diabetes."</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>In the adrenal glands, renewing
                        cells stream from the capsule on the surface of the gland toward the center of the gland. The
                        first cells to be produced in a regenerating gland are those that produce aldosterone, the next
                        in the stream are the cortisol producing cells, and the last to be formed are the cells that
                        produce the sex hormones, the androgens including DHEA, and progesterone. In aging, after the
                        age of thirty, the renewal slows, but the dissolution of the sex hormone zone continues, so the
                        proportion shifts, increasing the ratio of the aldosterone and cortisol producing cells to the
                        layer that produces the protective androgens and progesterone (Parker, et al., 1997).</span
                    ></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Even before aldosterone was
                        identified, progesterone's role in regulating the salts, water, and energy metabolism was known,
                        and after the functions of aldosterone were identified, progesterone was found to protect
                        against its harmful effects, as it protects against an excess of cortisol, estrogen, or the
                        androgens. New anti-aldosterone drugs are available that are effective for treating hypertension
                        and heart failure, and their similarity to progesterone is recognized.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>While stress typically causes the
                        adrenal glands to produce cortisol, extreme stress, as described by Hans Selye, damages the
                        adrenal cortex, and can cause the cells to die, leading to the death of the animal. There is
                        evidence that it is the breakdown of unsaturated fatty acids that causes damage to the adrenal
                        cortex in extreme stress. Although many factors influence the production of the adrenal
                        steroids, arachidonic acid, even without being converted to prostaglandins, is an important
                        activator of aldosterone synthesis. Adrenalin, produced in response to a lack of glucose,
                        liberates free fatty acids from the tissues, so when the tissues contain large amounts of the
                        polyunsaturated fatty acids, the production of aldosterone will be greater than it would be
                        otherwise.&nbsp;</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The continuing accumulation of
                        polyunsaturated fats in the tissues is undoubtedly important in the changing relationship
                        between the pancreas and the adrenal glands in aging. Aspirin, which is antilipolytic,
                        decreasing the release of free fatty acids, as well as inhibiting their conversion to
                        prostaglandins, lowers the production of stress-induced aldosterone, and helps to lower blood
                        pressure, if it's taken in the evening, to prevent the increase of free fatty acids during the
                        night. Aspirin increases insulin sensitivity. A low salt diet increases the free fatty acids,
                        leading to insulin resistance, increasing free fatty acids in the blood, and contributing to
                        atherosclerosis (Prada, et al., 2000; Mrnka, et al., 2000; Catanozi, et al., 2003; Garg, et al.,
                        2011).</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>The same factors that support or
                        interfere with cellular renewal in the pancreas and adrenal glands have similar effects in the
                        bones, skin, skeletal and heart muscle, nervous system, liver, and other organs. In every case,
                        the local circulation of blood is influenced by both local and systemic factors. The loss of
                        control over the water in the body is the result of energy failure, and hypertension is one of
                        the adaptations that helps to preserve or restore energy production.&nbsp;</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Lowering inflammation and the
                        associated excess of free fatty acids in the blood, and improving the ability to oxidize
                        glucose, will lower blood pressure while improving tissue renewal, but lowering blood pressure
                        without improving energy production and use will create new problems or intensify existing
                        problems. After 40 years the medical profession quietly retreated from their catastrophic
                        approach to pregnancy toxemia, but in the more general problem of essential hypertension, the
                        mistaken ideology is being preserved, even as less harmful treatments are introduced. That
                        ideology prevents a comprehensive and rational approach to the problems of stress and
                        aging.</span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
                &nbsp;&nbsp;&nbsp;&nbsp;<span style="font-family: Helvetica"><span><strong><h3>REFERENCES</h3></strong
                        ></span></span></span>
        </blockquote>
        <blockquote></blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Med Sci Monit. 2002
                        Jul;8(7):CR473-7.&nbsp;<strong>Effect of renin-angiotensin system activation by dietary sodium
                            restriction and upright position on plasma leptin concentration in patients with essential
                            hypertension.&nbsp;</strong>Adamczak M, Kokot F, Chudek J, Wiecek A.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Obesity (Silver Spring). 2006
                        Sep;14(9):1571-8.&nbsp;<strong>Associations between aortic calcification and components of body
                            composition in elderly men.&nbsp;</strong>Alexandersen P, TankÃ³ LB, Bagger YZ, Jespersen J,
                        Skouby SO, Christiansen C.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Am J Physiol Renal Physiol. 2008
                        Sep;295(3):F619-24.&nbsp;<strong>Brain cell volume regulation in hyponatremia: role of sex, age,
                            vasopressin, and hypoxia.&nbsp;</strong>Ayus JC, Achinger SG, Arieff A.&nbsp;&nbsp;</span
                    ></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Neurochem Res 1991
                        Mar;16(3):269-78.&nbsp;<strong>Alterations of GABA metabolism and seizure susceptibility in the
                            substantia nigra of the kindled rat acclimating to changes in osmotic state.</strong
                        >&nbsp;Baxter CF, Oh CC, Wasterlain CG, Ozaki LK, Baldwin RA.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Diabetes. 2012
                        Mar;61(3):560-1.&nbsp;<strong>Does inhibition of beta-cell proliferation by free fatty acid in
                            mice explain the progressive failure of insulin secretion in type 2 diabetes?&nbsp;</strong
                        >Boden G.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>BJOG. 2004
                        Sep;111(9):1020-2.&nbsp;<strong>Severe hyponatraemia and pre-eclampsia.&nbsp;</strong>Burrell C,
                        de Swiet M.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Stem Cells. 2010
                        Sep;28(9):1630-8.&nbsp;<strong>Pancreatic Î²-cell neogenesis by direct conversion from mature
                            Î±-cells.&nbsp;</strong>Chung CH, Hao E, Piran R, Keinan E, Levine F.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Eur Respir J Suppl. 2003
                        Nov;46:33s-40s.&nbsp;<strong>Fluid homeostasis in chronic obstructive lung
                            disease.&nbsp;</strong>de Leeuw PW, Dees A.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Trends Endocrinol Metab. 2011
                        Jan;22(1):34-43.&nbsp;<strong>Beta-cell regeneration: the pancreatic intrinsic faculty.</strong
                        >&nbsp;Desgraz R, Bonal C, Herrera PL.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Am J Physiol. 1993 May;264(5 Pt
                        1):E730-4.&nbsp;<strong>Effect of sodium intake on insulin sensitivity.</strong>Donovan DS,
                        Solomon CG, Seely EW, Williams GH, Simonson DC.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Nat Med. Novemeber 4,
                        1998.&nbsp;</span></span></span>
            <span style="color: #222222"><span style="font-family: Helvetica"><span><strong>Neurogenesis in the adult
                            human hippocampus.</strong></span></span></span>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>&nbsp;Eriksson, PS.,&nbsp;</span
                    ></span></span>
            <a href="http://et.al/" target="_blank"><span style="color: #1155cc"><span
                        style="font-family: Helvetica"
                    ><span>et.al</span></span></span></a>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>J Exp Med. 1996 May
                        1;183(5):1981-6.&nbsp;<strong>Vesiculo-vacuolar organelles and the regulation of venule
                            permeability to macromolecules by vascular permeability factor, histamine, and
                            serotonin.&nbsp;</strong>Feng D, Nagy JA, Hipp J, Dvorak HF, Dvorak AM.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Metabolism. 2011 Jul;60(7):965-8.
                        Epub 2010 Oct 30.&nbsp;<strong>Low-salt diet increases insulin resistance in healthy
                            subjects.</strong>&nbsp;Garg R, Williams GH, Hurwitz S, Brown NJ, Hopkins PN, Adler
                        GK.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>Curr Opin Endocrinol Diabetes Obes.
                        2012 Jun;19(3):168-75.&nbsp;<strong>Role of mineralocorticoid receptor in insulin
                            resistance.&nbsp;</strong>Garg R, Adler GK.</span></span></span>
        </blockquote>
        <blockquote>
            <span style="color: #222222"><span style="font-family: Helvetica"><span>J Clin Endocrinol Metab. 1991
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